Pharmacoepidemiol Drug Saf. 2013 Apr;22(4):345-58. doi: 10.1002/pds.3381. Epub 2012 Dec 6.
Statins in the prevention of dementia and Alzheimer's disease: a meta-analysis of observational studies and an assessment of confounding.
NCBI
Wong WB, Lin VW, Boudreau D, Devine EB.
Studies demonstrate the potential for statins to prevent dementia and Alzheimer's disease (AD), but the evidence is inconclusive.
OBJECTIVE:
Conduct a meta-analysis to estimate any benefit of statins in preventing dementia and examine the potential effect of study design and confounding on the benefit of statins in dementia. A secondary goal is to explore factors that may elucidate the mechanisms by which statins exert their potentially beneficial effect.
METHODS:
Performed systematic literature review to identify relevant publications. Relative risk (RR) estimates were pooled using both fixed and random effect models. Studies were stratified by study design and potential confounding factors.
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RESULTS:
The pooled results for all-type dementia suggest that use of statins is associated with a lower RR of dementia when compared to non-statin users (random effects model: RR 0.82 (95%CI [0.69, 0.97]). The pooled results for AD also suggested a lower RR with statin user compared to non-statin users in random effects models (RR: 0.70, 95% CI [0.60, 0.83]). Study design and methods used to address biases may influence the results.
CONCLUSION:
These pooled results suggest that statins may provide a slight benefit in the prevention of AD and all-type dementia. This benefit observed in both disease states should be interpreted with caution as observational studies are subject to bias, and it is possible that the slight benefit observed may disappear when these biases are addressed in a well-designed randomized controlled trial.
Showing posts with label dementia. Show all posts
Showing posts with label dementia. Show all posts
Sunday, January 19, 2014
Tuesday, July 6, 2010
Plant-based diet may help depression, dementia
Food Consumer
07/07/2010
A new study in the July 6, 2010, issue of Neurology suggests that having depression boosts risk of dementia like Alzheimer's disease.
This is only a suggestion because the study does not mean that depression causes dementia or vise versus.
The study involved 949 people at an average age of 79 years, who were free of dementia, but 125 of them were diagnosed with depression at the beginning of the study.
At the end of the 17-yer follow-up, 164 participants developed dementia; of those participants, 136 were diagnosed with Alzheimer's disease.
Jane Saczynski, PhD, author of the study from the University of Massachusetts Medical School in Worcester, MA and colleagues found 22 percent of those who had depression at baseline ended up developing dementia at the end of the study compared to 17 percent of those who were not depressed.
Dr. Saczyynski said even though depression may not necessarily cause dementia, it is possible that something like inflammation of brain tissue that contributes to depression boosts the risk of dementia like Alzheimer's.
Indeed, that is a possibility. Diet is one of the things that may affect risk of both depression and dementia.
A study led by Nanri A and colleagues from the National Center for Global Health and Medicine in Tokyo, Japan shows that a plant-based diet protects against depression.
Nanri found a healthy Japanese diet, consisting of high amounts of vegetables, fruit, mushrooms and soy products was associated with fewer depressive symptoms...
Food Consumer
07/07/2010
A new study in the July 6, 2010, issue of Neurology suggests that having depression boosts risk of dementia like Alzheimer's disease.
This is only a suggestion because the study does not mean that depression causes dementia or vise versus.
The study involved 949 people at an average age of 79 years, who were free of dementia, but 125 of them were diagnosed with depression at the beginning of the study.
At the end of the 17-yer follow-up, 164 participants developed dementia; of those participants, 136 were diagnosed with Alzheimer's disease.
Jane Saczynski, PhD, author of the study from the University of Massachusetts Medical School in Worcester, MA and colleagues found 22 percent of those who had depression at baseline ended up developing dementia at the end of the study compared to 17 percent of those who were not depressed.
Dr. Saczyynski said even though depression may not necessarily cause dementia, it is possible that something like inflammation of brain tissue that contributes to depression boosts the risk of dementia like Alzheimer's.
Indeed, that is a possibility. Diet is one of the things that may affect risk of both depression and dementia.
A study led by Nanri A and colleagues from the National Center for Global Health and Medicine in Tokyo, Japan shows that a plant-based diet protects against depression.
Nanri found a healthy Japanese diet, consisting of high amounts of vegetables, fruit, mushrooms and soy products was associated with fewer depressive symptoms...
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