Even Moderate Drinking Increases the Risk for Cancer
Zosia Chustecka
Medscape
April 08, 2011
April 8, 2011 — "A considerable proportion of the most common and most lethal cancers is attributable to former and current alcohol consumption," concludes a large European study published online April 8 in BMJ.
The researchers attribute about 10% of all cancers in men and about 3% of all cancers in women to previous and current alcohol consumption.
The estimates come from an analysis of data from the huge ongoing European Prospective Investigation Into Cancer (EPIC) and from representative data on alcohol consumption compiled by the World Health Organization (WHO).
The risk increases even with drinking moderate amounts.
"This research supports existing evidence that alcohol causes cancer and that the risk increases even with drinking moderate amounts," coauthor Naomi Allen, DPhil, an epidemiologist at Oxford University, United Kingdom, said in a statement.
The original data in the EPIC study were collected from 1992 to 2000, so "the results from this study reflect the impact of people's drinking habits about 10 years ago," Dr. Allen noted.
"People are drinking even more now than they were then, and this could lead to more people developing cancer because of alcohol in the future," she added.
Data From 8 Countries
The EPIC study, which is still ongoing, is one of the largest studies of diet and cancer ever conducted. It involved more than half a million people in Europe.
For this analysis of alcohol and cancer, the researchers used EPIC data from 363,988 participants from 8 European countries — France, Italy, Spain, the Netherlands, United Kingdom, Greece, Germany, and Denmark. Two of these centers (France and the Netherlands) recruited only women, so the total cohort was about two thirds female (254,870 women; 109,118 men).
Data on the incidence of cancer was obtained through record linkage with national cancer centers and from sources such as death certificates, health insurance records, and pathology reports.
Information on alcohol consumption was collected using a detailed questionnaire about the frequency and amount of drinking and the type of beverages consumed during the previous year. The researchers also computed data on alcohol exposure in the general population using data from a WHO survey.
Cancer Attributable to Alcohol
The researchers assumed a causal association between alcohol and cancer of the upper aerodigestive tract (which includes the oral cavity, pharynx, larynx, and esophagus), liver cancer, female breast cancer, and colorectal cancer (as decreed by the WHO's International Agency for Research on Cancer).
The team then calculated the proportion of these specific cancers that could be attributable to previous and current alcohol consumption. They estimated that, in 2008, alcohol was responsible for 44% of the upper aerodigestive tract cancers in men and 25% in women, 33% of liver cancer in men and 18% in women, 17% of colorectal cancer in men and 4% in women, and 5% of breast cancer in women.
A substantial portion of these cancers attributable to alcohol consumption was linked to drinking more than the currently recommended upper limit, the researchers note.
The World Cancer Research Fund and the American Institute for Cancer Research recommend a maximum of 2 drinks per day (about 28 g of alcohol) for men and 1 drink (about 12 g) for women.
The team calculated that drinking more than this was responsible for 57% to 87% of the cancers attributable to alcohol (i.e., upper aerodigestive tract, liver, colorectal, and female breast cancer) in men and from 40% to 98% in women.
"Our data show that many cancer cases could have been avoided if alcohol consumption is limited to 2 alcoholic drinks per day in men and 1 alcoholic drink per day in women, which are the recommendations of many health organizations," said lead author Madlen Schütze, PhD student and epidemiologist at the German Institute of Human Nutrition in Potsdam-Rehbrücke, Nuthetal, Germany.
"Even more cancer cases could be prevented if people reduced their alcohol intake to below recommended guidelines or stopped drinking alcohol altogether," she said in a statement.
Although a substantial portion of the cancers were attributable to high alcohol intake, the remaining cancers were attributable to drinking alcohol at or under the currently recommended levels.
Risk Increases With Every Drink
"The cancer risk increases with every drink, so even moderate amounts of alcohol — such as a small drink each day — increases the risk of these cancers," according to a press release from Cancer Research UK, which cosponsors the ongoing EPIC study, along with several European agencies.
"Many people just don't know that drinking alcohol can increase their cancer risk," said Sara Hiom, director of health information at Cancer Research UK.
"Cutting back on alcohol is one of the most important ways of lowering your cancer risk," along with not smoking and maintaining a healthy bodyweight, she said.
The researchers touch on this point in their discussion. They refer back to studies that have shown a beneficial effect of alcohol on death from cardiovascular disease, especially coronary heart disease and ischemic stroke, which have in the past led to recommendations to enjoy a drink to benefit the heart.
But they point out that "even though light to moderate alcohol consumption might decrease the risk for cardiovascular disease, and mortality, the net effect is harmful."
"Thus, alcohol consumption should not be recommended to prevent cardiovascular disease or all-cause mortality," they write.
No Sensible Limit
The researchers also emphasize that this latest study, in addition to several others, shows that "there is no sensible limit below which the risk of cancer is decreased."
This point was also made recently in an editorial in the Journal of the National Cancer Institute (2009;101:282-283), which accompanied findings from the British Million Women Study showing that even 1 drink a day significantly increased the risk for cancer (J Natl Cancer Inst. 2009;101:296-305).
There is no level of alcohol than can be considered safe.
At that time, editorialists Michael Lauer, MD, and Paul Sorlie, PhD, from the division of prevention and population sciences at the National Heart, Lung and Blood Institute in Bethesda, Maryland, wrote: "From a standpoint of cancer risk, the message of this report could not be clearer. There is no level of alcohol that can be considered safe."
BMJ. Published online April 8, 2011. Full text
Showing posts with label alcohol. Show all posts
Showing posts with label alcohol. Show all posts
Friday, May 23, 2014
Thursday, January 16, 2014
More than two drinks a day could speed memory loss: study
More than two drinks a day could speed memory loss: study
GMA News
January 16, 2014
WASHINGTON - Men who consume more than two alcoholic drinks per day while in middle age may speed up their memory loss in later life by up to six years, said a study Wednesday.
However, there were no differences in memory or mental function between non-drinkers and those who drank less than two drinks, or 20 grams per day, said the findings in the journal Neurology.
For the study, more than 5,000 middle-aged men were interviewed about their drinking habits three times over 10 years.
Then, they underwent memory and other cognitive tests beginning at an average age of 56. These tests were repeated twice over the next 10 years.
"Our study focused on middle-aged participants and suggests that heavy drinking is associated with faster decline in all areas of cognitive function in men," said study author Severine Sabia of the University College London.
The mental abilities of heavy drinkers declined between one-and-a-half to six years faster than those who had fewer drinks per day.
Men who drank 36 grams of alcohol or more per day saw the steepest declines in their memory and brain function.
Some 2,000 women were also included in the study, but there were not enough heavy drinkers among them to analyze their rates of mental decline compared to moderate or non-drinkers.
Neurology is the medical journal of the American Academy of Neurology. — Agence France-Presse
GMA News
January 16, 2014
WASHINGTON - Men who consume more than two alcoholic drinks per day while in middle age may speed up their memory loss in later life by up to six years, said a study Wednesday.
However, there were no differences in memory or mental function between non-drinkers and those who drank less than two drinks, or 20 grams per day, said the findings in the journal Neurology.
For the study, more than 5,000 middle-aged men were interviewed about their drinking habits three times over 10 years.
Then, they underwent memory and other cognitive tests beginning at an average age of 56. These tests were repeated twice over the next 10 years.
"Our study focused on middle-aged participants and suggests that heavy drinking is associated with faster decline in all areas of cognitive function in men," said study author Severine Sabia of the University College London.
The mental abilities of heavy drinkers declined between one-and-a-half to six years faster than those who had fewer drinks per day.
Men who drank 36 grams of alcohol or more per day saw the steepest declines in their memory and brain function.
Some 2,000 women were also included in the study, but there were not enough heavy drinkers among them to analyze their rates of mental decline compared to moderate or non-drinkers.
Neurology is the medical journal of the American Academy of Neurology. — Agence France-Presse
Thursday, January 2, 2014
Heavy drinking will literally rot your DNA
Heavy drinking will literally rot your DNA
Even occasional heavy drinking can have long-lasting impacts
National Monitor
Ian Lang
January 02, 2014
For some, college wouldn’t be worth attending were it not for the weekend alcohol benders: Week-long bouts of studiousness bookended by weekends of debauchery and heavy drinking. Provided you lay off the sauce more often than not, letting loose a couple of days per week never hurt anyone, right? Wrong. According to a new study, even sporadic instances of heavy drinking can damage DNA.
Coming out of Mexico, the study worked with university students to analyze the effect of weekend alcohol consumption on the lipids comprising cell membrane and its genetic material, i.e. DNA. This is the first study of its kind to examine the effect of alcohol on DNA during the early stages of alcohol abuse. Earlier studies ignored it, likely because they focused on subjects who had consumed alcohol in an addictive manner for some time.
Oddly enough, researcher Adela Rendón was prompted to launch the study when she observed college students acting like college students. While lecturing Clinical Biochemistry on a Monday morning, she noticed that students who had drank over the weekend were inattentive and out of sorts. She suspected that this was due to alcohol consumption and not because “Clinical Biochemistry” sounds like the most boring subject on Earth. She involved the students and went ahead with gathering experts and completing necessary administrative documents.
The eventual aim of the study? Oxidative damage caused by the consumption of alcohol beverages in young people.
The activity of the alcohol enzyme dehydrogenase, responsible for metabolizing ethanol into acetaldehyde, acetoacetate and acetone was measured. Oxidative damage is evaluated by a TBARS biochemical test (types that react to barbituric acid), and reflects the lipid peroxidation that affects the membrane due to the impact not only of the ethanol in the blood but also of the acetaldehyde produced by the action of the enzyme on the ethanol. That means there are at least two means by which free radicals are formed and which can damage cell membrane integrity.
Researchers were surprised not because they found results, but by the volume of those results.
“We saw that the ones who drank sustained twice as much oxidative damage compared with the group that did not consume alcohol,” Rendón said. Further examining cells via the “comet test” (used to measure damage to cell DNA), they found that students who drank had 5.3 times the number of damaged cells as those who abstained.
Scientists expect to observe that kind of damage in chronic alcohol abusers, but were surprised to see any damage at all stemming from a comparatively isolated instance of drinking.
“When we talk about youth alcohol abuse, we are referring to youngsters who drink alcohol without having become addicted. Addiction involves a more complex issue socially and psychologically speaking. This is social alcohol abuse,” said Rendón, “but which causes damage in the long term and you have to be aware of that.”
The harmful consumption of alcoholic beverages is a global issue and constitutes a significant health, social and economic problem. According to World Health Organisation data, alcohol is responsible for 2.5 million deaths a year worldwide and drinkers between the ages of 19 and 25 account for 320,000 of them...
Even occasional heavy drinking can have long-lasting impacts
National Monitor
Ian Lang
January 02, 2014
For some, college wouldn’t be worth attending were it not for the weekend alcohol benders: Week-long bouts of studiousness bookended by weekends of debauchery and heavy drinking. Provided you lay off the sauce more often than not, letting loose a couple of days per week never hurt anyone, right? Wrong. According to a new study, even sporadic instances of heavy drinking can damage DNA.
Coming out of Mexico, the study worked with university students to analyze the effect of weekend alcohol consumption on the lipids comprising cell membrane and its genetic material, i.e. DNA. This is the first study of its kind to examine the effect of alcohol on DNA during the early stages of alcohol abuse. Earlier studies ignored it, likely because they focused on subjects who had consumed alcohol in an addictive manner for some time.
Oddly enough, researcher Adela Rendón was prompted to launch the study when she observed college students acting like college students. While lecturing Clinical Biochemistry on a Monday morning, she noticed that students who had drank over the weekend were inattentive and out of sorts. She suspected that this was due to alcohol consumption and not because “Clinical Biochemistry” sounds like the most boring subject on Earth. She involved the students and went ahead with gathering experts and completing necessary administrative documents.
The eventual aim of the study? Oxidative damage caused by the consumption of alcohol beverages in young people.
The activity of the alcohol enzyme dehydrogenase, responsible for metabolizing ethanol into acetaldehyde, acetoacetate and acetone was measured. Oxidative damage is evaluated by a TBARS biochemical test (types that react to barbituric acid), and reflects the lipid peroxidation that affects the membrane due to the impact not only of the ethanol in the blood but also of the acetaldehyde produced by the action of the enzyme on the ethanol. That means there are at least two means by which free radicals are formed and which can damage cell membrane integrity.
Researchers were surprised not because they found results, but by the volume of those results.
“We saw that the ones who drank sustained twice as much oxidative damage compared with the group that did not consume alcohol,” Rendón said. Further examining cells via the “comet test” (used to measure damage to cell DNA), they found that students who drank had 5.3 times the number of damaged cells as those who abstained.
Scientists expect to observe that kind of damage in chronic alcohol abusers, but were surprised to see any damage at all stemming from a comparatively isolated instance of drinking.
“When we talk about youth alcohol abuse, we are referring to youngsters who drink alcohol without having become addicted. Addiction involves a more complex issue socially and psychologically speaking. This is social alcohol abuse,” said Rendón, “but which causes damage in the long term and you have to be aware of that.”
The harmful consumption of alcoholic beverages is a global issue and constitutes a significant health, social and economic problem. According to World Health Organisation data, alcohol is responsible for 2.5 million deaths a year worldwide and drinkers between the ages of 19 and 25 account for 320,000 of them...
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